Related Experiment Video
Updated: Apr 8, 2026

Development of Sulfidogenic Sludge from Marine Sediments and Trichloroethylene Reduction in an Upflow Anaerobic Sludge Blanket Reactor
Published on: October 15, 2015
Development of a RuHAP-Packed-Bed Reactor for Continuous Flow Aerobic Oxidation
Soocheon Lee1, Keunyoung Lee2, Ki-Young Kwon3
1Center for Metareceptome Research, Graduate School of Pharmaceutical Sciences, Chung-Ang University, 84 Heukseok-ro, Dongjak, Seoul 06974, Republic of Korea.
Abstract:
The aerobic oxidation of alcohols is valuable but often limited by toxic reagents, waste, and harsh conditions. Using a Ru3+-hydroxyapatite (RuHAP)-packed-bed reactor under low-pressure O2, we achieved efficient, reproducible oxidations with TONs of >18,000 after two catalyst regenerations. A two-step continuous flow process integrating oxidation and Knoevenagel condensation delivered products in excellent yields, demonstrating a scalable, safe, and sustainable method with high selectivity and mild conditions for fine chemical and pharmaceutical synthesis.
Related Concept Videos
Hydroboration-Oxidation of Alkenes
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Alkynes to Aldehydes and Ketones: Hydroboration-Oxidation
One of the convenient methods for the preparation of aldehydes and ketones is via hydration of alkynes. Hydroboration-oxidation of alkynes is an indirect hydration reaction in which an alkyne is treated with borane followed by oxidation with alkaline peroxide to form an enol that rapidly converts into an aldehyde or a ketone. Terminal alkynes form aldehydes, whereas internal alkynes give ketones as the final product.
Radical Oxidation of Allylic and Benzylic Alcohols
Bioreactor Design and Operational System
Bioreactor Controls-II

