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Updated: Jan 11, 2026
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Immunological Status of Saliva in Children with Asthma by Disease Severity
Svitlana Leshchuk1, Zaki Hakami2, Satish Vishwanathaiah3
1Department of Pediatric Dentistry, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Aim:
The primary goal of this study was to evaluate the immunological status of saliva in those children suffering from asthma based on the severity and duration of the disease's prevalence.
Materials And Methods:
A saliva test for the presence of immunoglobulins A (IgA) and G (IgG), and the secretory immunoglobulin A (sIgA) and lysozyme activity was conducted in 7, 12, and 15-year-old children suffering from asthma (main group) totaling 98 children in all and another 68 healthy children (control group) to observe and determine the local immunity levels in the oral cavity. Making use of the radial immunodiffusion method in agar gel, the concentration of IgA and IgG in the oral fluid was conducted as a part of the study. The evaluation of immunoglobulins in asthmatics was carried out, depending on the severity and duration of asthma.
Results:
Children suffering from asthma experienced a decrease in the local immunoglobulin mechanisms of saliva protection. Compared to the control group, asthmatic children displayed a lower level of sIgA by 2.0 times, IgA by 1.6 times, lysozyme by 2.2 times, and an increase in the level of IgG by 1.2 times.
Conclusions:
With the data obtained, it is clearly indicated that children suffering from asthma are subjected to decreased defense mechanism levels, which, in turn, could be the primary contributing factor for caries development in those children affected by asthma.
How To Cite This Article:
Leshchuk S, Hakami Z, Vishwanathaiah S. Immunological Status of Saliva in Children with Asthma by Disease Severity. Int J Clin Pediatr Dent 2025;18(10):1200-1206.
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