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Modular Design of Hydrogel Adhesives for Enhanced Tissue Healing
Kuan Zhang1,2,3, Yi Wei1, Han Ding1
1Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, China.
Advanced Materials (Deerfield Beach, Fla.)
|November 11, 2025
Summary
This study presents a modular hydrogel adhesive system using genetically engineered polypeptides for versatile biomedical applications. These adaptable bioadhesives offer strong adhesion and easy removal, enhancing wound hemostasis and healing.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Biomedical Engineering
Background:
- Hydrogel adhesives show promise in wound hemostasis and healing but lack adaptable strategies for complex biological environments.
- Existing hydrogel adhesives face limitations in achieving a balance between adhesive strength, cohesion, and tissue compatibility.
- The development of versatile and easily removable bioadhesives is crucial for advancing biomedical applications.
Purpose of the Study:
- To develop a modular hydrogel adhesive system with tunable properties for diverse biomedical applications.
- To engineer hydrogel adhesives that provide strong adhesion and cohesion while allowing for non-damaging removal.
- To demonstrate the broad applicability of the developed hydrogel bioadhesives in various in vivo and in vitro tissue models.
Main Methods:
- A modular design approach was employed, integrating genetically engineered polypeptides into hydrogel networks and protein coacervates.
- Distinct functional components were designed to synergistically achieve optimal adhesive strength and cohesion.
- The hydrogel bioadhesives were designed for mild triggering to enable easy and non-damaging tissue removal.
Main Results:
- The developed hydrogel adhesive system demonstrated a balance between adhesive strength and cohesion.
- The bioadhesives exhibited robust adhesion performance in liver, heart, and stomach models.
- Successful in vivo application for tissue wound hemostasis and healing was demonstrated, with easy and non-damaging removal.
Conclusions:
- The modular hydrogel adhesive system offers a versatile platform for biomedical applications, addressing limitations of current technologies.
- The engineered polypeptides and coacervate system provide tunable properties for enhanced adhesion and controlled removal.
- This innovative bioadhesive technology holds significant potential for improving wound management and tissue repair strategies.
