Related Experiment Video
Updated: Jan 11, 2026

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
Published on: March 2, 2020
4,4'-(Acridine-2,7-di-yl)bis-(2-methyl-but-3-yn-2-ol)
Masaki Yamamura1, Seira Ikuma2, Tatsuya Nabeshima2
1Center for Liberal Arts and Science Faculty of Engineering Toyama Prefectural University, 5180 Kurokawa Imizu Toyama 939-0398 Japan.
Abstract:
The title acridine derivative, C23H21NO2, which has two 2-methyl-but-3-yn-2-ol moieties at the 2,7-positions, was synthesized by Sonogashira coupling reaction. In the crystal, a columnar structure is formed by the π-π stacking of acridine units. The 2-methyl-but-3-yn-2-ol moieties form inter-molecular hydrogen bonds.
Related Concept Videos
Nomenclature of Alkynes
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis
Preparation of Diols and Pinacol Rearrangement
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.
α-Hydroxy Ketones via Reductive Coupling of Esters: Acyloin Condensation Overview

