Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Super-resolution Fluorescence Microscopy

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Design and Optimization of a Twisted Photodiode Pixel Structure for All-Directional Phase-Detection Autofocus CMOS Image Sensors.

Sensors (Basel, Switzerland)·2026

Same author

Therapeutic Targets for Bone and Soft-Tissue Sarcomas.

International journal of molecular sciences·2019

Same author

Risk factors for surgical site infection after malignant bone tumor resection and reconstruction.

BMC cancer·2019

Same author

A Scaffold-Free Allogeneic Construct From Adipose-Derived Stem Cells Regenerates an Osteochondral Defect in a Rabbit Model.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2019

Same author

The combination of gemcitabine and nab-paclitaxel as a novel effective treatment strategy for undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2019

Same author

[Development of Novel Osteoporosis Screening Methods Using FRAX].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2019

Search research articles

Related Experiment Video

Updated: Jan 11, 2026

Simultaneously Capturing Real-time Images in Two Emission Channels Using a Dual Camera Emission Splitting System: Applications to Cell Adhesion

Simultaneously Capturing Real-time Images in Two Emission Channels Using a Dual Camera Emission Splitting System: Applications to Cell Adhesion

Published on: September 4, 2013

Development of 3D-Stacked 1Megapixel Dual-Time-Gated SPAD Image Sensor with Simultaneous Dual Image Output

Kazuma Chida¹, Kazuhiro Morimoto¹, Naoki Isoda¹

¹Canon Inc., 70-1, Yanagi-cho, Saiwai-ku, Kawasaki 212-8602, Kanagawa, Japan.

Sensors (Basel, Switzerland)

|November 13, 2025

Summary

This study presents a novel 1-megapixel dual-time-gated SPAD image sensor for efficient sensor fusion. The sensor achieves simultaneous dual image output, enabling RGB-Depth sensing and high dynamic range imaging.

Keywords:

HDR RGB-D SPAD dual-time-gated sensor fusion

More Related Videos

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

Published on: August 16, 2012

Lensless Fluorescent Microscopy on a Chip

Lensless Fluorescent Microscopy on a Chip

Published on: August 17, 2011

Related Experiment Videos

Last Updated: Jan 11, 2026

Simultaneously Capturing Real-time Images in Two Emission Channels Using a Dual Camera Emission Splitting System: Applications to Cell Adhesion

Simultaneously Capturing Real-time Images in Two Emission Channels Using a Dual Camera Emission Splitting System: Applications to Cell Adhesion

Published on: September 4, 2013

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

Published on: August 16, 2012

Lensless Fluorescent Microscopy on a Chip

Lensless Fluorescent Microscopy on a Chip

Published on: August 17, 2011

Area of Science:

Photonics and Imaging Technology
Computational Imaging
Sensor Fusion

Background:

Sensor fusion is vital for imaging applications but faces computational challenges due to data integration from diverse sensors.
Existing time-gated single-photon avalanche diode (SPAD) sensors mitigate some issues but struggle with mismatched frame timing.
Previous dual-time-gated SPAD sensors had limitations like large pixel pitch, low resolution, and restricted exposure control.

Purpose of the Study:

To introduce a high-performance dual-time-gated SPAD image sensor.
To enable simultaneous dual image capture with synchronized timing, field-of-view, and resolution.
To validate its application in RGB-Depth sensing and high dynamic range imaging.

Main Methods:

Development of a 5 µm-pitch, 3D-backside-illuminated (BSI) 1-megapixel dual-time-gated SPAD image sensor.
Implementation of a novel high dynamic range (HDR) technique using in-pixel memories and pileup effect.
Verification of simultaneous dual image output without complex alignment.

Main Results:

The sensor successfully operates as an RGB-Depth sensor, simplifying sensor fusion.
A dynamic range of 119.5 dB was achieved using the novel HDR technique.
The developed sensor provides dual images with identical field-of-view, resolution, and frame timing.

Conclusions:

The proposed dual-time-gated SPAD image sensor architecture offers efficient sensor fusion capabilities.
Its ability to output synchronized dual images overcomes previous limitations.
This technology holds significant promise for advanced imaging and sensing systems.