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Updated: Jan 11, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
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HIV protease and its inhibition.

Stefano Rusconi1, Niccolò Paoletti2, Claudiu T Supuran2

  • 1Infectious Diseases Unit, Ospedale Civile di Legnano, ASST Ovest Milanese, Legnano (MI) - DIBIC, Università degli Studi di Milano, Milano, Italy.

The Enzymes
|November 14, 2025
PubMed
Summary

HIV protease (HPR) is crucial for HIV replication and a key drug target. This study details HPR structure, inhibition, clinical drugs, and resistance mechanisms to improve HIV treatment strategies.

Keywords:
Aspartic proteaseCombination therapyDrug resistanceHIVViral escape

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