Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Velopharyngeal Anatomy and Speech Production in Cleft Palate Surrounding Primary Palatoplasty: Protocol for a Prospective Observational Pilot Study.

JMIR research protocols·2026
Same author

Fast MRI for Pediatric Traumatic Brain Injury: What Findings Are Missed Compared with Routine MRI?

AJNR. American journal of neuroradiology·2026
Same author

ACR-ASNR-SPR Practice Parameter for the Performance of Computed Tomography Angiography (CTA) of the Head and Neck.

AJNR. American journal of neuroradiology·2026
Same author

Co-Presentation of Craniosynostosis and Ossified Cephalhematomas.

The Journal of craniofacial surgery·2025
Same author

Whimsy.

Radiology advances·2025
Same author

Accuracy of Tumor Surveillance of Pediatric Adamantinomatous Craniopharyngioma Using Noncontrast Brain MRI.

AJNR. American journal of neuroradiology·2025

Related Experiment Video

Updated: Jan 10, 2026

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

17.4K

Pediatric Diffuse Low-Grade Gliomas: Radiology, Symptoms, Treatment, and Molecular Pathways.

Andria M Powers1, Ilana Neuberger1

  • 1Department of Radiology, Children's Hospital Colorado, 13123 E. 16th Avenue, Box 125, Aurora, CO 80045, USA.

Neuroimaging Clinics of North America
|November 22, 2025
PubMed
Summary

Pediatric diffuse low-grade gliomas (LGGs) are diverse brain tumors in children. Current understanding integrates histopathology, genetics, and imaging for diagnosis and treatment.

Keywords:
Angiocentric glioma (AG)Diffuse astrocytomaDiffuse pediatric gliomaLow-grade gliomaMYB/MYBL1 alterationsMitogen-activated protein kinase (MAPK)Pediatric low-grade gliomaPolymorphous low-grade neuroepithelial tumors of the young (PLNTY)

More Related Videos

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
06:27

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

Published on: May 9, 2025

1.1K
Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma
09:06

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma

Published on: November 11, 2021

2.9K

Related Experiment Videos

Last Updated: Jan 10, 2026

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

17.4K
A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
06:27

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

Published on: May 9, 2025

1.1K
Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma
09:06

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma

Published on: November 11, 2021

2.9K

Area of Science:

  • Pediatric neuro-oncology
  • Central nervous system tumors

Background:

  • Pediatric diffuse low-grade gliomas (LGGs) are a distinct group of CNS tumors.
  • They differ from adult gliomas in behavior, molecular pathways, and presentation.
  • The WHO classification increasingly uses multimodal criteria.

Purpose of the Study:

  • To synthesize current knowledge on pediatric diffuse LGGs.
  • To cover clinical, molecular, and radiologic features.
  • To highlight diagnostic, treatment, and prognostic nuances.

Main Methods:

  • Literature synthesis of existing research.
  • Integration of histopathologic, genetic, and radiologic data.
  • Review of current WHO classification guidelines.

Main Results:

  • Pediatric LGGs are heterogeneous with varied clinical courses.
  • Molecular alterations are key to classification and understanding behavior.
  • Multimodal diagnostic criteria are essential for accurate subtyping.

Conclusions:

  • Accurate classification of pediatric diffuse LGGs is crucial.
  • Tailored treatment strategies are guided by integrated diagnostic data.
  • Understanding molecular drivers improves prognostic outlook.