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Hallmarks of the Aging Skin Microenvironment: Components and Mechanisms
Ruizhe He1,2, Mengzhe Sun1,2, Tiantian Liu1,2
1Department of Burns and Plastic Surgery and Department of Plastic and Reconstructive Surgery, Shanghai 9th Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Journal of Cellular Physiology
|November 25, 2025
Summary
The aging skin microenvironment drives skin aging through inflammation, cellular dysfunction, and impaired regeneration. Understanding these interconnected factors is key to developing novel anti-aging strategies.
Area of Science:
- Dermatology
- Aging Biology
- Cellular Biology
Background:
- Skin aging is a complex process involving cellular senescence and molecular dysfunction.
- The skin's microenvironment significantly contributes to and is affected by aging.
- A deeper understanding of the aging skin microenvironment is crucial for anti-aging research.
Purpose of the Study:
- To systematically review the aging skin microenvironment.
- To identify key components contributing to skin aging.
- To highlight potential targets for anti-aging interventions.
Main Methods:
- Systematic review of scientific literature.
- Framework analysis of the aging skin microenvironment.
- Elaboration of six interconnected components.
Main Results:
- The aging skin microenvironment involves inflammaging, immune dysfunction, ECM dysregulation, altered intercellular communication, physical changes, stem cell exhaustion, and microbiome dysbiosis.
- These factors create a self-reinforcing cycle of degradation and functional decline.
- The aging microenvironment exacerbates inflammation, oxidative stress, and barrier dysfunction.
Conclusions:
- The aging skin microenvironment is a critical driver of skin aging.
- Targeting these interconnected components offers promising avenues for novel anti-aging therapies.
- Further research into the aging skin microenvironment is essential for effective anti-aging strategies.
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