Antisocial and criminal behavior in Young onset dementia - A Narrative review

Antisocial and criminal behavior is an underrecognized aspect of neurodegenerative diseases. These behaviors are defined as behaviors and actions that violate the basic rights of others. Antisocial behaviors are seen in relatively high rates in behavioral variant frontotemporal dementia, but can be seen in other conditions. Several recent tools have been developed in attempt to quantify antisocial behaviors and neuroimaging studies have helped identify likely brain regions and networks involved in the genesis of antisocial behaviors. These regions include the anterior insula, ventral striatum, orbitofrontal cortex, and prefrontal cortices. The management of such symptoms is challenging with limited high quality studies available at this time. The recognition of antisocial behaviors can help limit complications. Further work is needed to more clearly delineate the pathophysiology of antisocial behavior.