Multifunctional Nanomaterial-Integrated Hydrogels for Sustained Drug Delivery: From Synthesis and Characterization to
Magdalena Stevanović1, Maja Jović1, Nenad Filipović1
1Group for Biomedical Engineering and Nanobiotechnology, Institute of Technical Sciences of SASA, Kneza Mihaila 35/IV, 11000 Belgrade, Serbia.
Gels (Basel, Switzerland)
|November 26, 2025
Summary
This review explores nanomaterial-integrated hydrogels for drug delivery. These advanced materials offer enhanced biocompatibility and tunable properties for improved therapeutic outcomes.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Hydrogels are excellent platforms for controlled drug delivery due to biocompatibility and tunable properties.
- Integrating functional nanomaterials enhances hydrogel functionality, enabling stimuli-responsive release and synergistic effects.
Purpose of the Study:
- To provide a comprehensive overview of nanomaterial-integrated hydrogels for biomedical applications.
- To discuss recent advances in design, fabrication, and characterization.
- To highlight emerging optimization strategies and smart hydrogel applications.
Main Methods:
- Review of nanoparticle synthesis and functionalization.
- Analysis of incorporation into hydrogel matrices.
- Evaluation of physicochemical and biological characterization methods.
Main Results:
- Nanomaterial integration offers enhanced bioactivity and controlled release.
- Comprehensive characterization includes cytotoxicity, genotoxicity, and bioactivity assessments.
- Machine learning and data-driven strategies show promise for optimization.
Conclusions:
- Nanomaterial-integrated hydrogels represent a significant advancement in drug delivery.
- Stimuli-responsive hydrogels offer vast potential for targeted therapies.
- Further research in optimization and smart hydrogels is crucial for clinical translation.
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