Recombinant Platelet-Derived Growth Factor-BB (rhPDGF-BB) Augmented Collagen Grafting for Oral Mucosal Defect...

Area of Science:

• Oral surgery
• Regenerative medicine
• Wound healing

Background:

• Oral mucosal defects require effective reconstruction methods.
• Collagen grafts are utilized for tissue repair.
• Growth factors may enhance regenerative processes.

Purpose of the Study:

• To evaluate collagen grafting for oral mucosal defects.
• To compare outcomes of rhPDGF-BB augmented collagen grafting versus collagen alone.

Main Methods:

• 30 patients with intraoral lesions were randomly assigned to two groups.
• Group I: collagen sheet with rhPDGF-BB.
• Group II: collagen sheet alone. Assessed hemostasis, pain, granulation, epithelialization, and contracture.

Main Results:

• Collagen grafting promoted hemostasis, pain relief, granulation, and epithelialization.
• rhPDGF-BB group showed slightly better granulation, epithelialization, and less contracture, though not statistically significant (p > 0.05).

Conclusions:

• Collagen graft augmented with rhPDGF-BB may benefit oral cavity reconstruction for small resections.
• Further research with larger sample sizes is recommended to confirm efficacy.