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Updated: May 5, 2026
Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate
Published on: September 11, 2013
Subretinal Fluid Duration and Clinical Outcomes in Central Serous Chorioretinopathy: An Analysis of
Ryoh Funatsu1, Naohisa Mihara1, Shoki Miyake1
1From the Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Objective:
To estimate the effect of prolonged serous retinal detachment (SRD) during the waiting period for photodynamic therapy (PDT) on clinical outcomes in patients with central serous chorioretinopathy (CSC).
Design:
Retrospective case series.
Subjects:
Consecutive patients with CSC who underwent PDT between January 2016 and August 2024. Patients whose SRD resolved spontaneously while awaiting PDT were excluded.
Methods:
We measured the best-corrected visual acuity (BCVA) and retinal layer thickness at baseline and on the day of PDT. We evaluated (1) the changes in these parameters during the waiting period and (2) the association between the duration of this period and the outcomes.
Main Outcome Measures:
Associations of the time-to-PDT with 12-month BCVA, SRD remission at 12 months, and changes in retinal layer thickness during the waiting period.
Results:
Ninety-four patients (94 eyes) with CSC were included, with a mean age of 57.6 ± 12.2 years, a mean BCVA of 0.18 ± 0.24 logMAR (Snellen: 20/30), and a mean waiting period of 50.8 ± 50.2 days. The outer nuclear layer thinned significantly during the waiting period (mean reduction = 1.9 ± 4.4 μm, P = 3.4 × 10-5), and longer waiting times were associated with greater thinning (crude: β = -0.04, P = 3.5 × 10-6; adjusted: β = -0.04, P = 1.3 × 10-6). However, waiting duration was not significantly associated with 12-month treatment outcomes.
Conclusions:
Our findings suggest that caution is warranted against prolonged subretinal fluid exposure beyond 1 to 2 months, as it may induce outer nuclear layer thinning.
