Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Dysrhythmias VI: Management of Dysrhythmias

Dysrhythmias VI: Management of Dysrhythmias

Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

12-Month Clinical Outcomes Using a Variable-Loop Circular Catheter for PFA in a Chinese Atrial Fibrillation Population.

Pacing and clinical electrophysiology : PACE·2026

Same author

EasyVoid: A Handheld Coandă Effect Uroflowmeter for Accurate and Portable Measurement of Urinary Flow Dynamics.

IEEE journal of translational engineering in health and medicine·2026

Same author

Influencing Factors and Prediction of Complications After Implantation of Cardiac Electronic Devices.

Pacing and clinical electrophysiology : PACE·2026

Same author

Comparative analysis of renal dysfunction, immune remodeling, and gut microbiota profiles in dietary models of metabolic liver disease.

BMC nephrology·2026

Same author

Screening for Clinically Significant Nephrolithiasis Based on Simple Health Checkup Clinical and Urine Parameters in General Populations: Multicenter Machine Learning Study.

JMIR medical informatics·2026

Same author

Pre-Existing Nocturia Status Predicts Bladder Symptom Exacerbation Following COVID-19 Vaccination in Women.

The Kaohsiung journal of medical sciences·2026

Search research articles

Related Experiment Video

Updated: Jan 9, 2026

Robotic Ablation of Atrial Fibrillation

Robotic Ablation of Atrial Fibrillation

Published on: May 29, 2015

Intraprocedural Trigger Stratification via Protocolized Isoproterenol Provocation: A Mappability-Guided Strategy for

Hui-Yi Liu^1,2, Meng-Meng Guo^1,2, Si-Jia Pu^1,2

¹Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Cardiology Research and Practice

|December 8, 2025

Summary

Continuous low-dose isoproterenol (ISP) effectively identifies atrial fibrillation (AF) triggers during conscious sedation. However, unmappable triggers are linked to significantly higher AF recurrence post-ablation, necessitating advanced mapping techniques.

Keywords:

catheter ablation isoproterenol provocation paroxysmal atrial fibrillation recurrence prediction substrate stratification trigger mappability

More Related Videos

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology

Published on: May 26, 2015

Programmed Electrical Stimulation in Mice

Programmed Electrical Stimulation in Mice

Published on: May 26, 2010

Related Experiment Videos

Last Updated: Jan 9, 2026

Robotic Ablation of Atrial Fibrillation

Robotic Ablation of Atrial Fibrillation

Published on: May 29, 2015

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology

Published on: May 26, 2015

Programmed Electrical Stimulation in Mice

Programmed Electrical Stimulation in Mice

Published on: May 26, 2010

Area of Science:

Cardiology
Electrophysiology
Medical Device Technology

Background:

Atrial fibrillation (AF) ablation success depends on identifying and eliminating arrhythmogenic triggers.
Current trigger identification methods may be limited, especially under conscious sedation.
Exploring novel provocative agents like isoproterenol (ISP) is crucial for enhancing procedural efficacy.

Purpose of the Study:

To assess the feasibility of using continuous low-dose ISP for identifying AF triggers during conscious sedation.
To investigate the correlation between unmappable triggers and the recurrence of AF after ablation procedures.

Main Methods:

Fifty patients with paroxysmal AF (PAF) received standardized ISP infusion (2-4 μg/min) to provoke triggers.
An adenosine triphosphate (ATP) challenge was administered if no arrhythmia was induced by ISP.
Pulmonary vein isolation (PVI) was performed, with additional ablation guided by identified triggers or operator discretion.

Main Results:

Provocative testing identified mappable triggers in 35 patients and unmappable triggers in 5 patients.
Patients with unmappable triggers experienced significantly higher AF recurrence (60.0%) at 12-month follow-up compared to those with mappable triggers (5.7%) or no inducible arrhythmia (0%).
The control group showed a recurrence rate of 14.6%.

Conclusions:

Continuous low-dose ISP infusion is a practical method for intraprocedural AF trigger identification under conscious sedation.
The high recurrence rate associated with unmappable triggers highlights the need for advanced mapping technologies to pinpoint arrhythmogenic sources.
Improved trigger localization may enhance AF ablation outcomes.