Related Experiment Video
Updated: Jan 9, 2026

Scale-up Chemical Synthesis of Thermally-activated Delayed Fluorescence Emitters Based on the Dibenzothiophene-S,S-Dioxide Core
Published on: October 24, 2017
Tandem Hydroxybenzothiophene Synthesis Mediated by LiN(SiMe3)2
Yuanyun Gu1, Kangyu Yin1, Yan-En Wang2
1State Key Laboratory of Materials Oriented Chemical Engineering (MCE), Technical Institute of Fluorochemistry (TIF), School of Chemistry and Molecular Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, P. R. China.
Abstract:
Benzothiophenes are pivotal heterocycles in pharmaceuticals due to their broad biological activities. Existing methods often require harsh conditions, toxic reagents, or expensive transition metals. Herein, we report a one-pot transition-metal-free synthesis of benzothiophenes using readily available methyl 2-fluorobenzoate, benzyl mercaptans, and LiN(SiMe3)2 under mild conditions. This protocol enables efficient access to a diverse array of 2-aryl-3-hydroxybenzothiophenes with excellent functional group tolerance. Furthermore, this approach enhances sustainability and simplifies synthetic workflows, offering a practical complement to existing benzothiophene synthesis.
More Related Videos
Related Concept Videos
Preparation and Reactions of Sulfides
Radical Substitution: Hydrogenolysis of Alkyl Halides with Tributyltin Hydride
The bonds formed in this reaction are stronger than the bonds broken, making it energetically favorable. The reaction follows a radical chain mechanism similar to radical halogenation reactions,...
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Benzene to Phenol via Cumene: Hock Process
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Cycloaddition Reactions: MO Requirements for Photochemical Activation

