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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

88
Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
88

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Related Experiment Video

Updated: May 2, 2026

Label-free Isolation and Enrichment of Cells Through Contactless Dielectrophoresis
10:38

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Published on: September 3, 2013

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Mm-Wave CMOS Biosensor With Integrated Dielectrophoresis for Single-Cell Detection and Characterization.

Ali Ameri, Ali M Niknejad

    IEEE Transactions on Biomedical Circuits and Systems
    |December 9, 2025
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a 114GHz sensor using an injection-locked voltage-controlled oscillator to detect single cells. On-chip dielectrophoresis (DEP) enhances measurement sensitivity and repeatability for cell analysis.

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    Area of Science:

    • Biophysics
    • Electrical Engineering
    • Microfluidics

    Background:

    • Accurate single-cell analysis is crucial for understanding biological processes and drug interactions.
    • Existing methods often lack the sensitivity, repeatability, or real-time monitoring capabilities required for dynamic cellular studies.

    Purpose of the Study:

    • To develop a high-frequency sensing platform for label-free detection and characterization of single mammalian cells.
    • To integrate on-chip dielectrophoresis (DEP) for precise cell manipulation and enhanced sensing.
    • To demonstrate the platform's capability in differentiating cell types and cellular states.

    Main Methods:

    • Fabrication of a 114GHz injection-locked voltage-controlled oscillator (IL-VCO) sensor in 28nm CMOS technology.
    • Integration of on-chip DEP generators for cell focusing and alignment.
    • Packaging with microfluidics enabling continuous sample handling via single-mask lithography.

    Main Results:

    • Successful detection and characterization of single mammalian cells at 114GHz.
    • Demonstrated differentiation of various materials and three distinct cell lines (HeLa GFP, HCT-116, SK-MEL-28).
    • Distinguished between growth and mitotic states within a single cell line, showcasing high sensitivity.

    Conclusions:

    • The developed IL-VCO sensor platform offers a novel approach for high-throughput, label-free single-cell analysis.
    • Integrated DEP and microfluidics significantly improve measurement sensitivity and repeatability.
    • This technology provides a foundation for streamlined cell-based assays and real-time drug-cell interaction monitoring.