Distinct mechanisms of cell in breast cancer and their clinical implication

Area of Science:

• Oncology
• Molecular Biology
• Cellular Biology

Background:

• Breast cancer is a globally prevalent, heterogeneous disease with significant morbidity.
• Despite therapeutic advances, novel targets are crucial due to molecular diversity and treatment complexity.
• Hallmarks of cancer include suppressed cell death, necessitating exploration of various cell death modalities.

Purpose of the Study:

• To systematically review the molecular mechanisms of diverse cell death pathways in breast cancer.
• To identify novel therapeutic targets and strategies based on cell death modulation.
• To provide insights for improved clinical management of breast cancer.

Main Methods:

• Systematic literature review of cell death pathways in breast cancer.
• Analysis of molecular underpinnings of apoptosis, anoikis, autophagy, necroptosis, ferroptosis, pyroptosis, and cuproptosis.
• Integration of findings to identify therapeutic opportunities.

Main Results:

• Cell death pathways are critically implicated in breast cancer development and progression.
• Targeting specific cell death mechanisms presents promising therapeutic avenues.
• Dysregulation of apoptosis and other cell death forms contributes to treatment resistance.

Conclusions:

• Modulating cell death pathways offers a promising strategy for novel breast cancer therapies.
• Further research into the intricate roles of diverse cell death types is warranted.
• Translating mechanistic insights into clinical practice can enhance breast cancer management.