Related Experiment Video
Updated: Jan 9, 2026
05:05
Ultrasound Cyclo Plasty in Eyes with Glaucoma
Published on: January 26, 2018
12.6K
Micropulse versus Slow Coagulation Transscleral Cyclophotocoagulation in Refractory Glaucoma: A Randomized Clinical
César R de Lima Neto1, Gabriel Ayub1, Samuel Goulart N E Silva1
1Department of Ophthalmology, University of Campinas, Campinas, Brazil.
Ophthalmology. Glaucoma
|December 10, 2025
Summary
Micropulse Transscleral Cyclophotocoagulation (MP-TSCPC) and Slow Coagulation Transscleral Cyclophotocoagulation (SC-TSCPC) both lower intraocular pressure (IOP) in refractory glaucoma. SC-TSCPC offers greater IOP reduction but carries a higher risk of complications.
Area of Science:
- Ophthalmology
- Glaucoma Treatment
- Surgical Innovation
Background:
- Refractory glaucoma poses a significant challenge to maintaining visual function.
- Transscleral cyclophotocoagulation (TSCPC) is an established treatment for advanced glaucoma.
- Comparing different TSCPC modalities is crucial for optimizing patient outcomes.
Purpose of the Study:
- To compare the efficacy and safety of Micropulse Transscleral Cyclophotocoagulation (MP-TSCPC) versus Slow Coagulation Transscleral Cyclophotocoagulation (SC-TSCPC).
- To evaluate outcomes over a 12-month follow-up period in patients with refractory glaucoma.
Main Methods:
- A parallel, double-arm, single-center, double-masked, randomized clinical trial was conducted.
- Eighty eyes of 80 patients with refractory glaucoma were randomized (1:1) to MP-TSCPC or SC-TSCPC.
- Primary outcome: mean intraocular pressure (IOP) reduction; Secondary outcomes: medication use, success rates, and complications.
Main Results:
- Both MP-TSCPC and SC-TSCPC significantly reduced IOP at 12 months (p < 0.001).
- SC-TSCPC demonstrated a greater mean IOP reduction (61%) compared to MP-TSCPC (52%) (p=0.03).
- SC-TSCPC had a higher incidence of complications (58.9%) including hypotony, compared to MP-TSCPC (35.1%).
Conclusions:
- Both MP-TSCPC and SC-TSCPC are effective in reducing IOP in refractory glaucoma.
- SC-TSCPC provides superior IOP reduction but is associated with increased postoperative complications.
- Preoperative IOP >30mmHg or early postoperative IOP >15mmHg are predictors of surgical failure.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
928
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
928
01:28Angle Closure Glaucoma: Treatment
1.1K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.1K
01:25Glaucoma: Overview
1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K