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Updated: Jan 8, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Rhodium(III)-Catalyzed Three-Component Diamination of Bicyclo[1.1.0]butanes via Nitrene Transfer
Shunle Hu1, Lijuan Jv1, Ruijie Mi1
1Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237, China.
Abstract:
Rhodium-catalyzed three-component diamination of bicyclo[1.1.0]butanes (BCBs) has been realized for the synthesis of 1,1,3,3-tetrasubstituted cyclobutanes. This ring-opening reaction of BCBs is strain-release-driven, and the trivalent rhodium catalyst facilitates the 1,3-diamination reaction through accommodation of both nucleophilic (aniline) and electrophilic (dioxazolone) nitrogen sources. The reaction exhibits high regio- and diastereoselectivity. The flexibility of this synthetic approach is demonstrated in various downstream transformations.
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