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Clinical Manifestations.

Christopher A Phillips1, Cory A Alcon1, Sam N Lockhart2,3

  • 1High Point University, High Point, NC, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Cognitive function and education predict grocery shopping success in younger and older adults. Higher amyloid-beta levels in older adults were associated with poorer performance on this complex task.

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Area of Science:

  • Neuroscience
  • Cognitive Aging
  • Biomarkers

Background:

  • Understanding how Alzheimer's disease (AD) biomarkers, such as brain amyloid-beta (Aβ), and cognitive reserve influence performance on complex tasks is crucial for early intervention.
  • This study investigates the predictive power of demographics, social factors, cognitive abilities, and Aβ deposition on grocery shopping performance in young (YA) and older adults (OA).

Purpose of the Study:

  • To determine if demographic, social, cognitive, and Aβ deposition factors predict grocery shopping performance in young and older adults.
  • To explore differences in these predictive relationships between age groups.

Main Methods:

  • Fifty-four older adults (OA) and 28 young adults (YA) without cognitive impairment completed four grocery shopping trials using eye-tracking.
  • Performance metrics included grocery note fixations and time spent fixating on correct items/shelving.
  • Predictors included demographics (education, age), social factors (household size), cognitive tests (MoCA, Coding, SSI, ICI), and Aβ PET scans (OA only).

Main Results:

  • In YA, poorer cognitive scores (MoCA, ICI) predicted more grocery note fixations, while less education predicted more time on correct shelving/brand.
  • In OA, older age, higher Aβ, and better processing speed (Coding) predicted more grocery note fixations.
  • Better cognitive scores (Coding, MoCA) predicted more efficient visual search (less time on incorrect areas) in OA, particularly with lower Aβ.

Conclusions:

  • Cognitive abilities and education are key predictors of grocery shopping performance across age groups.
  • Higher brain Aβ levels are associated with less efficient visual scanning during grocery shopping in older adults.
  • Findings highlight the role of cognition and Aβ in complex task performance and aging.