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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Direct Synthesis of (Radio)difluoromethylated Selenides via Organic Photoredox Catalysis
Yi Fang1,2,3, Jingwen Li1,2, Chunyi Liu1
1National Health Commission Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China.
Abstract:
Herein we describe a practical synthesis of difluoromethylated selenides enabled by organophotoredox catalysis. A diverse range of functionalized selenides were efficiently constructed from selenosulfonates and commercially available BTSO2CF2H, affording moderate to excellent yields under mild conditions. The protocol features low catalyst loading and operational simplicity. Moreover, this approach has been successfully translated to 18F-difluoromethylation with high radiochemical conversion, thus providing a streamlined route to potential PET imaging agents.
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