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Optimizing Psychological Treatment for Pain After Breast Cancer Using a Randomized Factorial Design: A Feasibility

Cecilie Rask Buskbjerg1,2, Maja Johannsen3, Caroline Cecilie Nørskov1

  • 1Department of Psychology and Behavioral Sciences, Aarhus University, Aarhus, Denmark.

Scandinavian Journal of Psychology
|December 31, 2025
PubMed
Summary
This summary is machine-generated.

This study found that components of third-wave cognitive behavioral therapy are feasible, acceptable, and safe for managing persistent pain after breast cancer (BC). Further trials are recommended to evaluate optimized interventions using the Multiphase Optimization Strategy (MOST).

Keywords:
cancer painfeasibility studiesintervention optimizationpsycho‐oncologysurvivorshipthird wave cognitive behavioral therapy

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Area of Science:

  • Psychology
  • Oncology
  • Behavioral Science

Background:

  • Persistent pain is a common challenge for breast cancer (BC) survivors.
  • Psychological interventions show promise but require optimization for improved efficacy.
  • Third-wave cognitive behavioral therapy (CBT) components offer potential therapeutic avenues.

Purpose of the Study:

  • To evaluate the feasibility of delivering third-wave CBT components for persistent pain after BC.
  • To assess the acceptability, validity, and safety of these components using the Multiphase Optimization Strategy (MOST).
  • To inform the development of an optimized intervention for post-BC pain.

Main Methods:

  • Mixed-methods study employing a factorial experimental design with online delivery.
  • Randomization of participants to eight conditions based on zero, one, two, or three treatment components (Mindful Attention, Decentering, Values and Committed Action).
  • Assessment of pain intensity, pain interference, and change processes, supplemented by semi-structured interviews.

Main Results:

  • No major barriers to engagement, treatment validity, or participant satisfaction were identified.
  • No significant increases in pain outcomes or adverse effects were observed across treatment components.
  • The study procedures and treatment components were deemed acceptable, valid, and safe.

Conclusions:

  • The feasibility, acceptability, and safety of using MOST to develop optimized psychological interventions for post-BC pain are demonstrated.
  • The findings support proceeding with larger trials to evaluate the efficacy of individual and combined treatment components.
  • This research paves the way for more effective management of persistent pain in breast cancer survivors.