Recent advances in engineering nano/microrobots for tumor treatment

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Nanomedicines show promise in cancer treatment by reducing side effects and improving drug efficacy.
• Current nanomedicines face challenges in targeted drug delivery, including accuracy, tumor penetration, and systemic toxicity.

Purpose of the Study:

• To review recent advancements in nano/microrobots for tumor treatment.
• To explore the working mechanisms and functionalities of different nano/microrobot-driven modes.
• To discuss the application of various materials in nano/microrobot fabrication for cancer therapy.

Main Methods:

• Review of current literature on nano/microrobots in oncology.
• Detailed analysis of nano/microrobot working principles and functionalities based on different driving modes.
• Elaboration on material science aspects of nano/microrobot construction for therapeutic applications.

Main Results:

• Nano/microrobots exhibit enhanced capabilities like real-time sensing, manipulation, and programmability.
• Different driven modes enable active navigation, precise drug release, and automated tumor treatment.
• These robots demonstrate potential for improved tumor penetration, payload retention, and minimized off-target damage.

Conclusions:

• Nano/microrobots represent a significant advancement over traditional nanomedicines for tumor treatment.
• Further research and development are crucial for clinical translation, addressing key factors for successful implementation.
• Nano/microrobots hold immense potential for revolutionizing cancer therapy through targeted and efficient interventions.