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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
Highly stable self-assembled nanotubes from a bipyridinium-based amphiphilic pseudopeptide
Alejandro Vila1, Valentina Gauci1, Arturo Blanco-Gómez1
1Interdisciplinary Center for Chemistry and Biology (CICA) and Department of Chemistry, Faculty of Science, University of Coruña, 15071 A Coruña, Spain. arturo.blanco.gomez@udc.es.
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Herein, we report an amphiphilic pseudopeptide that spontaneously self-assembles into monodisperse cationic nanotubes under physiological conditions. These nanotubes exhibit fast self-assembly, remarkable thermal stability and thermoreversibility. The self-assembly concentration range is exceptionally broad, enabling the formation of stable hydrogels at concentrations above 5 mM while preserving the nanostructure at micromolar levels.

