Visible-Light-Promoted Cascade Radical Trifluoromethylation/Cyclization for the Synthesis of Trifluoromethylated...

Tricyclic quinoxalinonyl compounds represent an important class of tricyclic fused N-heterocyclic systems widely distributed in pharmaceutical agents and biologically active molecules. Herein, we described a visible-light-induced radical trifluoromethylation/cyclization reaction using cost-effective and readily available CF₃Br as the trifluoromethyl source. This strategy enables, for the first time, the efficient construction of a series of trifluoromethylated tricyclic quinoxalinonyl compounds from N-(isopentenyl)quinoxalin-2(1H)-ones and N-homoallylquinoxalin-2(1H)-ones via radical trifluoromethylation/cyclization. The method features mild reaction conditions and excellent functional group compatibility and can be extended to various fluoroalkyl reagents such as C₆F₁₃Br and C₈F₁₇Br, providing a mild and efficient synthetic approach for introducing diverse fluoroalkyl groups to organic compounds.