Related Experiment Video
Updated: Jan 13, 2026

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
Published on: August 13, 2013
Tissue-resident regulatory T cells: modulators of local immunity
Yun Shi1, Lingling Wang2, Chuntong Bao3
1Department of Immunology and Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
None:
Regulatory T cells (Tregs) have gained renewed attention for their diverse roles beyond immune suppression. This review integrates recent discoveries on how tissue-resident Tregs integrate immune, metabolic, and neural cues to maintain organ homeostasis and regeneration. Across adipose tissue, intestine, brain, and skin, Tregs coordinate local networks that couple immune tolerance with metabolic balance and tissue repair. We further discuss therapeutic advances - including antigen-specific chimeric antigen receptor (CAR)/T cell receptor (TCR) Tregs, interleukin 2 (IL-2) muteins, and metabolic modulation - that aim to harness Tregs for treating autoimmunity and chronic inflammation. Together, these insights highlight Tregs as central interpreters of tissue context and as promising targets for next-generation precision immunotherapy.
More Related Videos
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Cell-mediated Immune Responses
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Lymphoid Cells and Tissues
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

