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Genetic Engineering and Encapsulation Strategies for Lacticaseibacillus rhamnosus Enhanced Functionalities and
Leontina Grigore-Gurgu1, Florentina Ionela Leuștean-Bucur1, Gabriela-Elena Bahrim1
1Faculty of Food Science and Engineering, "Dunărea de Jos" University of Galati, 800008 Galați, Romania.
Foods (Basel, Switzerland)
|January 10, 2026
Summary
Genetic engineering enhances Lacticaseibacillus rhamnosus for industrial and health uses. Safety regulations and characterization challenges impact the market feasibility of these genetically modified (GM) probiotics.
Area of Science:
- Microbiology and Genetic Engineering
- Functional Foods and Nutraceuticals
Background:
- Lacticaseibacillus rhamnosus offers significant health benefits beyond traditional probiotics.
- Genetic engineering advances aim to improve L. rhamnosus properties for industrial and health applications.
Purpose of the Study:
- To review recent genetic engineering advances for L. rhamnosus.
- To evaluate the market feasibility and safety of genetically modified (GM) L. rhamnosus strains.
- To highlight the impact of L. rhamnosus bioactives on the gut-organ axis and associated diseases.
Main Methods:
- Review of recent literature on genetic engineering of L. rhamnosus.
- Analysis of in vivo functions and molecular mechanisms of L. rhamnosus.
- Evaluation of encapsulation systems for L. rhamnosus delivery.
Main Results:
- Genetic engineering offers potential for improved L. rhamnosus strains.
- L. rhamnosus bioactives show promise in mitigating obesity, metabolic disorders, depression, and Parkinson's disease.
- Encapsulation technologies enhance the stability and delivery of L. rhamnosus and its postbiotics.
Conclusions:
- GM L. rhamnosus strains present therapeutic potential but face regulatory and safety hurdles.
- Further research is needed to fully characterize and ensure the safety of GM L. rhamnosus for market introduction.
- L. rhamnosus holds significant promise as a functional food ingredient for managing complex health conditions.
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