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Updated: Jan 17, 2026

Bone Marrow-derived Macrophage Production
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Primitive macrophages take a road less traveled

Jessie Axsom1, F Chris Bennett1

  • 1Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Immunity
|January 14, 2026
PubMed
Summary

This study identifies a unique transcriptional program from primitive hematopoiesis essential for developing brain-resident macrophages. Understanding ontogeny reveals how shared factors create distinct macrophage lineages.

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