Related Experiment Video
Updated: Jan 18, 2026
Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Update to RIFM fragrance ingredient safety assessment, 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized, CAS
A M Api1, A Bartlett1, D Belsito2
1Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.
Abstract:
1,6-Octadien-3-ol, 3,7-dimethyl-, acid-isomerized was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data show that 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized is not genotoxic. Data on 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose toxicity and reproductive toxicity endpoints. Data show that there are no safety concerns for 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized for skin sensitization under the current declared levels of use. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized is not expected to be photoirritating/photoallergenic. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized is below the TTC (0.47 mg/day). The environmental endpoints were evaluated; 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
