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An Updated Insight into the Phytomolecules Reported for the Treatment of Colon Cancer from 2015 to 2024
Zulfa Nooreen1, Awani Kumar Rai1, Poonam Jaisal1
1Department of Pharmacy, PSIT-Pranveer Singh Institute of Technology (Pharmacy), Bhauti Kanpur, Uttar Pradesh, 209305, India.
Anti-Cancer Agents in Medicinal Chemistry
|January 26, 2026
Summary
Phytochemicals show promise in managing colon cancer, a growing global health concern. This review details natural compounds and their mechanisms against colon cancer, offering potential therapeutic strategies.
Area of Science:
- Gastroenterology
- Oncology
- Pharmacology
Background:
- Colon cancer prevalence has risen globally over the past two decades.
- Dietary habits and lifestyle factors contribute to increased colon cancer mortality.
- A diet low in fiber is linked to colon carcinogenesis.
Purpose of the Study:
- To compile and review phytochemicals with reported efficacy in colon cancer management.
- To analyze the mechanisms of action of various natural compounds against colon cancer.
Main Methods:
- Comprehensive literature search across major scientific databases (Web of Science, PubMed, Scopus, etc.).
- Inclusion of studies published between 2015 and 2020 focusing on phytochemicals and colon cancer.
- Analysis of identified compounds and their documented effects on cancer pathways.
Main Results:
- Numerous phytochemicals demonstrate anti-colon cancer properties.
- These compounds target key signaling pathways including inflammation, cell cycle, autophagy, apoptosis, metastasis, and angiogenesis.
- Specific examples include Ellagitannin, Ursolic acid, Curcumin, and Resveratrol, among others.
Conclusions:
- Phytochemicals offer a potential therapeutic avenue for colon cancer management.
- Understanding their mechanisms of action can guide future drug development.
- Despite poor prognosis, natural compounds present a hopeful approach for combating colon cancer.
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