Biodegradable Antibacterial Nanostructured Coatings on Polypropylene Substrates for Reduction in Hospital Infections...

Area of Science:

• Biomaterials Science
• Infectious Disease Control
• Nanotechnology

Background:

• Healthcare-associated infections (HCAIs) pose a significant global health threat due to persistent pathogens on hospital surfaces.
• Current infection control measures, such as disinfection and personal protective equipment, are often insufficient for complete microbial eradication.
• There is a critical need for innovative antimicrobial surface technologies to enhance patient safety and reduce infection rates.

Purpose of the Study:

• To design, prepare, and characterize novel antibacterial coatings based on chitosan and poly(ε-caprolactone) (PCL).
• To incorporate chlorhexidine-loaded zirconium phosphate (ZrPCHX) nanoparticles into these coatings for enhanced antimicrobial activity.
• To evaluate the efficacy of these nanostructured coatings in preventing microbial contamination on hospital surfaces.

Main Methods:

• Coatings were developed using chitosan and PCL polymers, incorporating ZrPCHX nanoparticles loaded with chlorhexidine.
• Optimized spray and brush deposition techniques were employed to create uniform and adherent films.
• Comprehensive characterization included morphological, physicochemical, mechanical, and cytocompatibility assessments.
• Antibacterial efficacy was tested against relevant pathogens using ISO 22196:2011 standards and simulated hospital conditions.

Main Results:

• Both chitosan- and PCL-based coatings demonstrated significant antibacterial activity against tested pathogens.
• The PCL-based formulation exhibited a faster and broader spectrum of bactericidal effect.
• The coatings maintained good cytocompatibility, indicating safety for use in healthcare environments.
• Characterization confirmed uniform film deposition and desirable material properties.

Conclusions:

• The developed nanostructured coatings show great promise for active decontamination of high-touch hospital surfaces.
• These materials offer a sustainable and scalable solution for continuous antimicrobial protection.
• The coatings have the potential to significantly contribute to reducing the incidence of healthcare-associated infections.