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Updated: Jan 30, 2026
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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Characterisation of the Novel HLA-C*07:1226 Allele by Next Generation Sequencing
Julien Lion1, Thomas Froidure1, Judith Desoutter1
1Department Histocompatibility, Amiens University Medical Centre, Amiens, France.
HLA
|January 29, 2026
Summary
A novel Human Leukocyte Antigen (HLA) C allele, HLA-C*07:1226, has been identified. It differs from the common HLA-C*07:01:01:01 allele by a single nucleotide substitution in exon 4.
Area of Science:
- Immunogenetics
- Molecular Biology
Background:
- Human Leukocyte Antigen (HLA) genes are highly polymorphic.
- Specific HLA alleles play critical roles in immune responses and transplantation outcomes.
Purpose of the Study:
- To report the characterization of a newly identified HLA-C allele.
Main Methods:
- Nucleotide sequencing of the HLA-C gene.
- Comparison of the novel sequence with known HLA-C alleles.
Main Results:
- A new HLA-C allele, designated HLA-C*07:1226, was discovered.
- This allele differs from HLA-C*07:01:01:01 by one non-synonymous nucleotide substitution at position 2278 in exon 4.
Conclusions:
- The identification of HLA-C*07:1226 expands the known HLA allele registry.
- This finding contributes to the understanding of HLA polymorphism and may have implications for immunogenetic studies.
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