Characterisation of the Novel HLA-C*03:741 Allele by Next Generation Sequencing
Julien Lion1, Ségolène Bartczak1, Judith Desoutter1
1Department Histocompatibility, Amiens University Medical Centre, Amiens, France.
HLA
|March 13, 2026
Summary
A novel Human Leukocyte Antigen (HLA) allele, HLA-C*03:741, has been identified. This new allele is distinguished from HLA-C*03:04:01:01 by a single nucleotide difference in exon 2.
Area of Science:
- Immunogenetics
- Molecular Biology
- Human Leukocyte Antigen (HLA) system
Background:
- The Human Leukocyte Antigen (HLA) complex plays a critical role in immune response and transplantation.
- Accurate HLA typing is essential for matching donors and recipients and understanding immune-mediated diseases.
Purpose of the Study:
- To report the identification and characterization of a novel HLA allele.
- To detail the specific genetic variation distinguishing this new allele from a known one.
Main Methods:
- High-resolution HLA typing techniques were employed.
- Nucleotide sequencing of relevant exons was performed to identify variations.
Main Results:
- A new HLA allele, designated HLA-C*03:741, was discovered.
- This allele differs from HLA-C*03:04:01:01 by a single non-synonymous nucleotide substitution at position 729 in exon 2.
Conclusions:
- The identification of HLA-C*03:741 expands the known HLA allele repertoire.
- This finding contributes to the precision of HLA typing and population genetics studies.
