Exploring the Potential of Phytotherapeutics against Auto-inflammatory Disorders: A Review

Various inflammatory conditions, such as arthritis, neuralgia, soft tissue injuries, and neuropathic pain, significantly affect daily quality of life. Among these, Osteoarthritis (OA) and Rheumatoid Arthritis (RA) are the most common types, often leading to joint discomfort and reduced quality of life. Conventional treatments like NSAIDs, though effective for pain relief, are associated with adverse effects, including an increased risk of cardiovascular disease. This review aims to highlight the potential role of herbal medicines in managing arthritis and reducing inflammation.

A review of studies was conducted using databases such as PubMed and Google Scholar, covering literature up to 2025. Experimental animal models like collagen-induced, CFA-induced, and carrageenan-induced arthritis in rats were considered. A total of 182 relevant articles were reviewed.

Herbal formulations have been shown to reduce inflammatory cytokines such as TNF- α, IL-1, IL-10, and IL-18, while also minimizing oxidative stress and joint inflammation. These findings support their therapeutic application in inflammatory disorders.

The review focuses on medicinal plants known for their anti-inflammatory and anti- arthritic activities, supported by both traditional usage and scientific evidence. Notable plantbased compounds discussed include curcumin, Terminalia chebula, and Moringa oleifera, all of which have shown promise in managing arthritis symptoms.

Despite regulatory and standardization challenges, herbal medicines demonstrate significant potential in treating arthritis. Their effectiveness in controlling inflammation and oxidative damage may lead to wider acceptance and use in future clinical practice.