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Prevalence and Risk of Anxiety and Depression after Concussion: A TRANSCENDENT Study
Jacqueline J van Ierssel1, Stephen A Kutcher1, Sharon Johnston2,3
1Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.
Journal of Neurotrauma
|February 1, 2026
Summary
High rates of anxiety and depression symptoms are common after concussion, affecting nearly half of patients. Risk factors include injury type, pre-existing anxiety, and sleep issues, necessitating routine screening and targeted treatment.
Area of Science:
- Neurology
- Psychiatry
- Public Health
Background:
- Anxiety and depression significantly impact quality of life post-concussion.
- Understanding prevalence and risk factors is crucial for timely intervention.
Purpose of the Study:
- To estimate the prevalence of moderate-to-severe anxiety (msANX) and depression (msDEP) symptoms after concussion.
- To identify patient-related and injury-related risk factors for these symptoms.
Main Methods:
- Prospective observational study in specialty concussion clinics.
- Recruited adolescents and adults with confirmed concussion.
- Assessed msANX (GAD-7 ≥10) and msDEP (PHQ-9 ≥10) at intake.
Main Results:
- 45.2% experienced msANX; 60.7% experienced msDEP.
- Risk factors included motor vehicle collisions, workplace injuries, preinjury anxiety, sleep difficulties, being female, and time since injury.
Conclusions:
- Prevalence estimates may underestimate symptom burden in specialty clinics.
- Routine screening for mental health conditions is recommended.
- Prioritize high-risk patients for monitoring and timely mental health referrals.
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