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Updated: Feb 7, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
Oral Squamous Cell Carcinoma in Non-Users of Tobacco: A 10-Year Single Institutional Retrospective Study
Kalpa Pandya1, Vijaya Nirmala Subramani2, K Shanthi3
1Department of Oral and Maxillofacial Surgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.
Background:
Oral squamous cell carcinoma (OSCC) comprises a significant proportion of head and neck cancers, with alarming incidence rates in India. Despite tobacco's known role, a concerning rise in OSCC among non-tobacco users poses an intriguing challenge.
Objective:
This ten-year retrospective study aimed to compare the clinicopathological features of OSCC in patients with and without habits, focusing on the unique characteristics of OSCC in non-tobacco users.
Methods:
Reviewing clinical records from 2012 to 2022, we gathered demographic and histopathological data, conducting statistical analyses using SPSS version 19.
Results:
83% of the subjects with OSCC had a known history of tobacco use, and 17% were non-tobacco users. Non-tobacco users exhibited distinct features, including a higher prevalence of well-differentiated SCC, more females, and an increased incidence of tongue cancers-statistically significant findings.
Conclusion:
This study highlights the unique clinicopathological features of OSCC in non-tobacco users, challenging conventional notions. Despite limitations in survival analysis, our findings underscore the need for targeted research into OSCC among non-tobacco users for improved preventive and therapeutic strategies. The study successfully confirmed the clinical distinctiveness of non-tobacco-induced oral cancers, setting the stage for future prospective research into the survival and prognosis of these two distinct groups.
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