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Updated: Feb 13, 2026
11:29
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
11.3K
LENG8-AS1: A Prognostic Biomarker in Colorectal Cancer-Differential Expression and Clinical Implications
Pardis Jafarnia1, Mohammad Mahdevar2,3, Maryam Peymani1
1Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
Indian Journal of Clinical Biochemistry : IJCB
|February 12, 2026
Summary
This study identifies LENG8-AS1 as a long non-coding RNA (lncRNA) biomarker in colorectal cancer (CRC). Upregulated LENG8-AS1 expression correlates with poor prognosis and tumor progression in CRC patients.
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Colorectal cancer (CRC) is a prevalent malignancy with distinct gene expression profiles.
- Long non-coding RNAs (lncRNAs) play a significant role in cancer development.
- Understanding lncRNA expression patterns is crucial for identifying novel biomarkers and therapeutic targets in CRC.
Purpose of the Study:
- To investigate the expression patterns of the antisense long non-coding RNA (lncRNA) LENG8-AS1 in colorectal cancer (CRC).
- To evaluate the impact of LENG8-AS1 expression on the survival outcomes of CRC patients.
- To explore the potential of LENG8-AS1 as a prognostic biomarker for CRC.
Main Methods:
- Utilized The Cancer Genome Atlas (TCGA) data and TCGA Biolinks for lncRNA candidate identification.
- Performed Cox regression analysis to correlate lncRNA expression with patient survival.
- Employed Kaplan-Meier plots for survival prediction modeling and RT-qPCR for expression validation in CRC tissues.
Main Results:
- Identified several lncRNAs, including LENG8-AS1, associated with CRC prognosis.
- Found LENG8-AS1 to be upregulated in CRC tissues and correlated with genes in lipid metabolism and angiogenesis pathways.
- Kaplan-Meier and ROC curve analyses indicated LENG8-AS1's potential as a prognostic biomarker for CRC.
Conclusions:
- LENG8-AS1 is upregulated in colorectal cancer and linked to poor patient prognosis.
- LENG8-AS1 may serve as a valuable biomarker for predicting CRC progression and patient survival outcomes.
- Further research into LENG8-AS1's role in CRC pathogenesis is warranted.
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