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BIOMARKERS OF CARDIOMETABOLIC RISK IN PATIENTS WITH ARTERIAL HYPERTENSION: A CROSS-SECTIONAL PILOT STUDY

G Derbissalina1, Z Bekbergenova1, A Umbetzhanova1

  • 11NJSC "Astana Medical University", Astana, Republic of Kazakhstan.

Georgian Medical News
|February 13, 2026
PubMed

Insights

Cardiometabolic biomarkers like waist circumference, BMI, and LDL-C are linked to cardiovascular disease in hypertensive patients in Kazakhstan. Further research is needed to understand region-specific risk factors.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Arterial hypertension is a major risk factor for cardiovascular disease.
  • Cardiometabolic biomarkers play a crucial role in assessing cardiovascular risk.
  • Understanding regional variations in cardiometabolic risk is essential for targeted interventions.

Purpose of the Study:

  • To comprehensively assess cardiometabolic biomarkers in patients with arterial hypertension.
  • To analyze the relationship between these biomarkers and coronary artery disease (CAD) and atherosclerosis.
  • To identify potential region-specific cardiometabolic risk patterns in Kazakhstan.

Main Methods:

  • A pilot study involving 31 patients with established arterial hypertension.
  • Assessment of anthropometric indicators (waist circumference, BMI), lipid parameters (LDL-C, total cholesterol, triglycerides), and systolic blood pressure.
  • Evaluation of biomarker associations with documented coronary artery disease and atherosclerosis.

Main Results:

  • Strongest associations with CAD and atherosclerosis were found for waist circumference, BMI, LDL-C, total cholesterol, triglycerides, and systolic blood pressure.
  • Elevated lipoprotein(a) levels were observed in some patients without confirmed disease, suggesting potential subclinical vascular involvement.
  • Findings align with previously described cardiometabolic patterns in the Kazakhstani population.

Conclusions:

  • Comprehensive assessment of anthropometric and biochemical biomarkers aids in early cardiovascular risk stratification for hypertensive patients in Kazakhstan.
  • Observed trends suggest potential region-specific features of cardiometabolic risk.
  • Further investigation in larger cohorts is warranted to confirm these region-specific findings.
Abstract

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