Related Experiment Video
Updated: Feb 28, 2026
Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
Published on: December 7, 2012
Pathogen-Reduce Cryoprecipitate: An Overview of Method(s) in Pathogen Reduction, Transfusion-Transmitted Infection
1Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, 700 Children's Drive, Building C, Room C1882, Columbus, OH 43205, USA; Department of Pathology, The Ohio State University College of Medicine, Columbus, OH, USA.
Cryoprecipitated-AHF is a blood derivative produced from plasma donations. It is been used to treat Hemophilia A, von Willebrand disease, and congenital/acquired hypofibrinogenemia, and historically implicated with transmission of serious infectious diseases. As testing and treatment modalities have improved, treatment indications have narrowed considerable, but it still carries the highest potential risk of transfusion-transmitted infection (TTI). Pathogen-reduced cryoprecipitate availability has virtually eliminated the risk of pathogen transmission and extended the shelf-life to minimize waste in clinical practice. This article reviews methods of pathogen reduction, their effectiveness at reducing TTIs, and examine real-world experience of its implementation on inventory management.
Cryoprecipitated-AHF is a blood derivative produced from plasma donations. It is been used to treat Hemophilia A, von Willebrand disease, and congenital/acquired hypofibrinogenemia, and historically implicated with transmission of serious infectious diseases. As testing and treatment modalities have improved, treatment indications have narrowed considerable, but it still carries the highest potential risk of transfusion-transmitted infection (TTI). Pathogen-reduced cryoprecipitate availability has virtually eliminated the risk of pathogen transmission and extended the shelf-life to minimize waste in clinical practice. This article reviews methods of pathogen reduction, their effectiveness at reducing TTIs, and examine real-world experience of its implementation on inventory management.
More Related Videos
10:32Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
Published on: August 24, 2015
11:31Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
Published on: November 30, 2015
Related Concept Videos
01:17Transmission-based Precautions I: Contact, Enteric, and Droplets
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
01:25Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
01:22Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
01:20Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
01:26Standard Precaution
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
02:45Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...