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Global trends in systemic sclerosis-related mortality, 2001-2023: an epidemiological analysis using World Health
Keith Pardillada Belangoy1, Yoshito Nishimura2, Ko Harada3
1Department of Health Data Science, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, 7008558, Japan.
Global mortality from systemic sclerosis (SSc) shows declining age-standardized rates but increasing crude rates, with women disproportionately affected. Targeted strategies are crucial for high-risk populations and regions.
Area of Science:
- Epidemiology
- Autoimmune Diseases
- Public Health
Background:
- Systemic sclerosis (SSc) is a severe autoimmune disease with significant mortality risk.
- Understanding global mortality trends is crucial for public health initiatives.
Purpose of the Study:
- To analyze global trends in systemic sclerosis (SSc)-related mortality.
- To examine variations by age, sex, and geographic region.
Main Methods:
- Utilized World Health Organization Mortality Database (2001-2023).
- Analyzed crude mortality rates (SSc-CRs) and age-standardized mortality rates (SSc-ASMR).
- Employed locally weighted and Joinpoint regression for trend analysis.
Main Results:
- 85,291 SSc deaths reported across 74 countries; 79.41% in females.
- SSc-CR increased, while SSc-ASMR decreased globally.
- Highest mortality in Western Pacific; decline in Americas and Europe; highest SSc-ASMR in middle SDI countries.
Conclusions:
- Global age-standardized SSc mortality is declining, but crude rates are rising, with a persistent female predominance.
- Disparities in SSc mortality persist across regions and sociodemographic factors.
- Emphasizes the need for continued research, enhanced disease awareness, and targeted interventions for high-risk groups.
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