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Racial Disparities Associated with Non-Infectious Anterior Uveitis and Concurrent Ocular Conditions: Results from a
Enny Oyeniran1, Abhisri Ramesh2, Rahul Raiker3
1NJEye and Ear, Englewood, New Jersey, USA.
Ocular Immunology and Inflammation
|March 12, 2026
Summary
Non-Hispanic White patients with anterior uveitis (AU) had higher odds of legal blindness and epiretinal membrane. Black and Hispanic patients with AU were more likely to have glaucoma. This highlights racial disparities in ocular comorbidities.
Area of Science:
- Ophthalmology
- Public Health
- Health Disparities
Background:
- Anterior uveitis (AU) is a significant cause of vision loss.
- Understanding racial and ethnic differences in AU comorbidities is crucial for targeted interventions.
- Previous studies have not fully elucidated the disparities in concurrent ocular conditions among diverse AU patient populations.
Purpose of the Study:
- To investigate the association between race/ethnicity and the likelihood of concurrent ocular conditions in patients diagnosed with non-infectious anterior uveitis (AU).
- To compare the odds of specific ocular comorbidities between non-Hispanic White patients and other racial/ethnic groups (non-White, Black, Hispanic) diagnosed with AU.
Main Methods:
- Utilized the TriNetX database to identify adult patients with incident non-infectious AU diagnoses via ICD-10 codes.
- Compared non-Hispanic White patients with AU against three distinct cohorts: non-White, Black, and Hispanic patients.
- Calculated odds ratios (OR) and 95% confidence intervals (CI) to assess the likelihood of concurrent ocular conditions at the time of AU diagnosis.
Main Results:
- Non-Hispanic White patients with AU showed increased odds of legal blindness (OR: 1.994) and epiretinal membrane (OR: 1.794) compared to non-White patients.
- Non-Hispanic White patients had lower odds of glaucoma (OR: 0.853), glaucoma suspect (OR: 0.797), and open-angle glaucoma (OR: 0.53) compared to Black patients.
- Non-Hispanic White patients had lower odds of cataracts (OR: 0.755), glaucoma (OR: 0.706), and glaucoma suspect (OR: 0.743) compared to Hispanic patients.
Conclusions:
- Non-Hispanic White patients with AU face higher risks for legal blindness and epiretinal membrane.
- Black and Hispanic patients diagnosed with AU exhibit a greater likelihood of glaucoma and related conditions.
- Findings underscore significant racial and ethnic disparities in the ocular comorbidities associated with anterior uveitis, necessitating culturally sensitive and equitable care strategies.
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