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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Updated: Mar 14, 2026

Murine Dermal Fibroblast Isolation by FACS
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Pediatric Dermatomyofibroma Case Series.

Katharina W Horn1, Alejandro A Gru2, Laura E Levin3

  • 1Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA.

Pediatric Dermatology
|March 12, 2026
PubMed
Summary
This summary is machine-generated.

Dermatomyofibroma (DMF) is a rare benign skin tumor in children. This study reviewed 21 pediatric cases, noting common neck locations and diagnostic challenges, and detailed unusual presentations and follow-up.

Keywords:
dermatomyofibromadermatopathologyfibrohistiocytic tumor

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Area of Science:

  • Dermatology
  • Pediatric Pathology
  • Oncology

Background:

  • Dermatomyofibroma (DMF) is a rare benign dermal neoplasm.
  • Pediatric DMF is exceptionally uncommon, with limited case reports available.
  • Accurate clinical and histological differentiation from other cutaneous lesions is crucial.

Purpose of the Study:

  • To characterize the clinicopathological features of pediatric dermatomyofibroma.
  • To describe unusual presentations of pediatric DMF.
  • To review post-biopsy follow-up in pediatric DMF cases.

Main Methods:

  • Histologically confirmed cases of pediatric DMF were identified from a dermatopathology database.
  • A retrospective review of 21 pediatric DMF cases was conducted.
  • Clinical data and follow-up information were extracted from patient charts for seven patients.

Main Results:

  • Twenty-one cases of pediatric DMF were identified.
  • The majority of affected children were male, with lesions predominantly on the neck.
  • Clinical presentation often mimicked other benign skin lesions like dermatofibromas and cysts, posing diagnostic challenges.

Conclusions:

  • Pediatric DMF, though rare, requires careful consideration in the differential diagnosis of pediatric neck masses.
  • Unusual presentations and post-biopsy outcomes warrant further investigation.
  • Histopathological confirmation remains essential for definitive diagnosis and management planning.