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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
[Deprescribing methadone for chronic non-cancer pain: management of withdrawal symptoms]
Anne Mette Drastrup1,2, Randi Eltved1, Carina Lundby3,4
1Smerteklinik Silkeborg, Center for Planlagt Kirurgi, Regionshospital Silkeborg.
Abstract:
In this case report, a 60-year-old patient was referred to a multidisciplinary pain clinic to discontinue methadone. Before referral, a self-managed dose reduction from 40 to 15 mg had led to loss of function due to withdrawal symptoms. After referral, methadone was successfully deprescribed over three months. Withdrawal symptoms were managed through an individually tailored plan, supportive consultations with a nurse, and the use of clonidine. The patient regained function after deprescribing methadone. Deprescribing opioids can be managed through a patient-centered approach and close monitoring.
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