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XMP-Net: An XAI-Based Modified Xception Model for Recognizing Monkeypox and Other Skin Diseases
Ferdib-Al-Islam1, Prithvi Biswas1, Partha Protim Gharami1
1Department of Computer Science and Engineering, Northern University of Business and Technology, Khulna, Bangladesh.
Biomed Research International
|March 25, 2026
Summary
A novel deep learning model, XMP-Net, accurately identifies monkeypox and other skin conditions. Explainable AI techniques enhance diagnostic confidence for these diseases.
Area of Science:
- Artificial Intelligence
- Medical Imaging
- Dermatology
Background:
- Accurate and timely diagnosis of skin conditions is crucial for effective treatment and public health.
- Emerging infectious diseases like monkeypox require rapid and reliable diagnostic tools.
- Deep learning offers potential for automated skin condition classification from images.
Purpose of the Study:
- To develop and evaluate XMP-Net, a modified Xception-based deep learning model for classifying skin conditions.
- To specifically enhance the identification of monkeypox among normal skin, chickenpox, and measles.
- To improve model interpretability using Grad-CAM and LIME for clinical trust.
Main Methods:
- Utilized a modified Xception architecture (XMP-Net) for image classification.
- Trained the model on a dataset of four skin condition categories: normal, chickenpox, measles, and monkeypox.
- Employed Grad-CAM and LIME for visual explanation of model predictions.
Main Results:
- XMP-Net achieved high accuracy: 98.33% for normal, 98.25% for monkeypox, 84.21% for measles, and 77.27% for chickenpox.
- Monkeypox classification showed strong performance with 91.80% precision, 98.25% recall, and 94.92% F1-score.
- Explainable AI methods highlighted image regions crucial for accurate classification.
Conclusions:
- XMP-Net demonstrates significant potential for accurate skin condition diagnosis, especially for monkeypox.
- Explainable AI integration enhances the interpretability and clinical utility of deep learning models.
- The research provides a foundation for developing accessible diagnostic tools for resource-limited settings.
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