Microsecond Dynamics of the Pyrophosphate Ion Release in SARS-CoV2 RNA Polymerase

Tiantian Xu1,2, Lin Yang3,4, Xinzhou Xu3,4

  • 1State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.

JACS Au
|March 27, 2026
PubMed
Summary

The release of pyrophosphate (PPi) from viral RNA-dependent RNA polymerase (RdRp) is crucial for replication. This study reveals a distinct PPi release mechanism in SARS-CoV-2 RdRp involving conserved residues and a stepwise process.

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