Characterisation of the Novel HLA-DRB1*12:119 Allele by PacBio Sequencing
Shihang Zhou1, Wanzhen Yu2, Suning Bai2
1Dalian Blood Center, Dalian, Liaoning, China.
HLA
|March 30, 2026
Summary
A novel HLA-DRB1 allele, HLA-DRB1*12:119, has been identified. It differs from a known allele by a single nucleotide substitution in exon 5 and intronic alterations.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- The human leukocyte antigen (HLA) system plays a critical role in immune responses.
- Polymorphisms within HLA genes, particularly HLA-DRB1, are associated with various immune-related conditions.
Purpose of the Study:
- To report the characterization of a newly identified HLA-DRB1 allele, designated HLA-DRB1*12:119.
- To describe the genetic variations distinguishing this new allele from previously known ones.
Main Methods:
- Nucleotide sequencing of exons and introns of the HLA-DRB1 gene.
- Comparative analysis of the novel allele's sequence against existing HLA database entries.
Main Results:
- A new HLA-DRB1 allele, HLA-DRB1*12:119, was identified.
- This allele differs from HLA-DRB1*12:02:01:01 by a single nucleotide substitution located in exon 5.
- Additional differences were noted in the intronic regions.
Conclusions:
- The discovery of HLA-DRB1*12:119 expands the known allelic diversity within the HLA-DRB1 locus.
- Understanding these specific genetic variations is crucial for high-resolution HLA typing and immunological studies.
