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Updated: Apr 1, 2026
Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
Published on: December 23, 2016
Development of a progressive HIV-1-Like infection model in northern pig-tailed macaques using stHIV-1sv/G53D
Tian-Zhang Song1, Qing Li1,2, Li-Rong Zhang1,3
1State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, People's Republic of China.
None:
Simian immunodeficiency virus (SIV) and simian-human immunodeficiency virus (SHIV) infections in nonhuman primates closely approximate human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), but intrinsic viral differences limit translational relevance. A physiologically accurate HIV-1 model remains elusive. Here, we established a progressive HIV-1-like infection model using northern pig-tailed macaques (NPMs) infected with stHIV-1sv/G53D and monitored for 200 days. Results showed persistent viremia, progressive CD4+ T-cell depletion, and influenza-like symptoms, mirroring clinical features of HIV-1 infection. Infected macaques recapitulated T-cell exhaustion, innate immune activation, chronic immunosuppression, multi-organ biomarker alterations, and microbial dysbiosis. Transient and attenuated antiviral immunity may underlie this disease trajectory. In summary, this model serves as a complementary platform for validating direct antiviral strategies targeting HIV-1.
