Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Effects of Injectable Biostimulatory Agents (Calcium Hydroxyapatite, New Cellular Treatment Factor, VAMP, and Human Exosomes) and Their Combination on Skin Regeneration.

Aesthetic surgery journal. Open forum·2026
Same author

Plant Exosome Injection with or without Low Level Laser Therapy Promotes Skin Wound Healing: An Experimental Study.

Plastic and reconstructive surgery. Global open·2026
Same author

Plant Exosome Injection: A New Boost for Postlaser Vascular Repair.

The Journal of clinical and aesthetic dermatology·2026
Same author

Plant Exosome Injections in Tongue Wounds: A Comparative Histological and Immunohistochemical Experimental Study.

Plastic and reconstructive surgery. Global open·2026
Same author

Human Derived Exosome Injections (ASCE+ vs. CELLEXOSOME) Enhance Collagen Remodeling and Angiogenesis in Intact Skin: A Comparative Experimental Study.

Journal of cosmetic dermatology·2026
Same author

Effects of New Cellular Treatment Factor and Human Exosome Injection on Intact Skin Regeneration in a Randomized In Vivo Study.

Plastic and reconstructive surgery. Global open·2026

Related Experiment Video

Updated: Apr 30, 2026

A Novel Method for the Culture and Polarized Stimulation of Human Intestinal Mucosa Explants
06:38

A Novel Method for the Culture and Polarized Stimulation of Human Intestinal Mucosa Explants

Published on: May 1, 2013

13.6K

Oral Mucosa Remodeling Induced by Injecting New Cellular Treatment Factor (NCTF) and Human-derived Exosomes (ASCE &

Noury Adel1, Jack Kolenda2

  • 1Oral and Maxillofacial Surgery Specialist, Private Practice, Cairo, Egypt.

Plastic and Reconstructive Surgery. Global Open
|April 10, 2026
PubMed
Summary

New Cellular Treatment Factor (NCTF) combined with exosomes promotes oral mucosa regeneration. Cell-derived exosomes showed superior enhancement of angiogenesis and collagen remodeling in a hamster model.

More Related Videos

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
12:16

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model

Published on: May 18, 2015

11.1K
Author Spotlight: Investigating Wound Healing in Mice Models of Oronasal Fistulas
03:51

Author Spotlight: Investigating Wound Healing in Mice Models of Oronasal Fistulas

Published on: September 8, 2023

2.0K

Related Experiment Videos

Last Updated: Apr 30, 2026

A Novel Method for the Culture and Polarized Stimulation of Human Intestinal Mucosa Explants
06:38

A Novel Method for the Culture and Polarized Stimulation of Human Intestinal Mucosa Explants

Published on: May 1, 2013

13.6K
Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
12:16

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model

Published on: May 18, 2015

11.1K
Author Spotlight: Investigating Wound Healing in Mice Models of Oronasal Fistulas
03:51

Author Spotlight: Investigating Wound Healing in Mice Models of Oronasal Fistulas

Published on: September 8, 2023

2.0K

Area of Science:

  • Regenerative Medicine
  • Tissue Engineering
  • Oral Mucosal Biology

Background:

  • Exosomes are key mediators of tissue regeneration, influencing angiogenesis, fibroblast activity, and extracellular matrix remodeling.
  • New Cellular Treatment Factor (NCTF) solutions are utilized in regenerative medicine, but their synergistic effects with human exosomes on oral mucosa are not well-understood.
  • This study investigates the combined impact of NCTF and distinct human exosome formulations on oral mucosa regeneration.

Purpose of the Study:

  • To evaluate the histological and immunohistochemical changes in hamster oral mucosa after treatment with NCTF enriched with two different human exosome formulations.
  • To compare the regenerative effects of NCTF combined with cell-derived exosomes versus adipose stem cell-derived exosomes.
  • To assess the time-dependent regenerative potential of these combined treatments.

Main Methods:

  • Sixty-three male hamsters were divided into three groups: saline control, NCTF with cell-derived exosomes (CellExosome), and NCTF with adipose stem cell-derived exosomes (ASCEs).
  • Treatments were injected into the buccal mucosa, with tissue harvesting at baseline, day 3, and day 7.
  • Histological analyses included Hematoxylin-eosin, Masson trichrome, and Van Gieson staining; angiogenesis was assessed via CD34 immunohistochemistry.

Main Results:

  • Both exosome-treated groups exhibited increased fibroblast proliferation, collagen organization, and microvessel density from day 3 to day 7 compared to controls.
  • The NCTF + CellExosome group demonstrated significantly enhanced angiogenesis and extracellular matrix remodeling at all time points (P < 0.05).
  • A time-dependent regenerative effect was observed in exosome-treated groups.

Conclusions:

  • Exosome-enriched biorevitalization solutions significantly enhance angiogenesis and collagen remodeling in normal oral mucosa.
  • The NCTF + CellExosome formulation displayed superior regenerative potential compared to ASCEs.
  • These findings support the translational relevance of NCTF and exosome combinations for future regenerative and aesthetic applications.