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Updated: Apr 14, 2026

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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
Published on: January 2, 2015
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A timeline of tau-mediated synaptotoxicity
Calum K Bonthron1, Claire S Durrant1
1Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.
Trends in Neurosciences
|April 12, 2026
Abstract:
Oligomeric tau has been increasingly implicated in synaptic impairments observed in Alzheimer's disease. In a recent study, Pareja-Navarro and colleagues provide insights into the precise timeline of synaptic deficits induced by oligomeric forms of tau. Such knowledge could aid in the design of therapeutic interventions to prevent synaptic loss.
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