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Exploring the Implementation of Community Pharmacist-Initiated Human Immunodeficiency Virus Post-Exposure
Grace T Marley1,2, Fatimah Hussein1, Amanda H Corbett1
1University of North Carolina Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.
Journal of the American College of Clinical Pharmacy : JACCP
|April 20, 2026
Summary
Most North Carolina pharmacists are willing to dispense HIV post-exposure prophylaxis (PEP) despite low awareness of the statewide protocol. Increased training and reimbursement are key to successful implementation of pharmacist-initiated HIV PEP.
Area of Science:
- Public Health
- Pharmacology
- Health Policy
Background:
- North Carolina authorized pharmacists to dispense HIV post-exposure prophylaxis (PEP) in 2022 via a statewide protocol.
- A survey assessed community pharmacists' knowledge, acceptability, and feasibility regarding pharmacist-initiated HIV PEP.
- Barriers and facilitators to implementing this new service were also evaluated.
Purpose of the Study:
- To evaluate North Carolina community pharmacists' understanding and willingness to dispense HIV post-exposure prophylaxis (PEP) under a statewide protocol.
- To identify barriers and facilitators impacting the implementation of pharmacist-initiated HIV PEP.
- To inform future strategies for expanding access to HIV prevention services.
Main Methods:
- An online survey was distributed to practicing North Carolina community pharmacists.
- Data collection occurred between March and April 2025, with descriptive statistics reported.
- The survey assessed awareness, knowledge, willingness, perceived benefits, and barriers related to dispensing HIV PEP.
Main Results:
- Of 447 eligible respondents, 50% were unaware of the statewide protocol for dispensing HIV PEP.
- While 48.5% felt slightly knowledgeable about HIV PEP regimens, 68.7% were willing to initiate it.
- Key barriers included lack of time, staff, training, and financial reimbursement.
Conclusions:
- Most North Carolina pharmacists are willing to dispense HIV PEP, despite limited awareness of the protocol.
- Enhanced insurance coverage for pharmacist services and comprehensive training are crucial for successful implementation.
- Pharmacist-initiated HIV PEP has the potential to increase community access to preventative care and reduce HIV transmission.

