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A Quality-by-Design Approach Based Formulation, Optimization, In Vitro and Ex Vivo Evaluation of Delafloxacin-Loaded

Deesha Jain1, Devaraj Yallappa1, Modhusmita Gogoi2

  • 1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Palaj, Gandhinagar, Gujarat, 382355, India.

AAPS Pharmscitech
|April 23, 2026
PubMed
Summary

This study developed a delafloxacin (DFX) ethosomal (ETHs) gel for enhanced topical delivery and antibacterial action against skin infections. The optimized DFX-ETHs gel demonstrated improved efficacy and safety for treating bacterial skin conditions.

Keywords:
C acneS aureusBox Behnken designdelafloxacinethosomesquality by designtopical gel

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